Li J, Ross JL, Hambardzumyan D, Brat DJ. Immunopathology of Glioblastoma. Annu Rev Pathol. 2025 Oct 8. doi: 10.1146/annurev-pathmechdis-042524-025950. Epub ahead of print. PMID: 41061166.
Li, J., Shih, L. K., Markwell, S. M., Olson, C. L., Sullivan, D. P., Arvanitis, C., Ross, J. L., Lam, N. G., Nuszen, H., Hambardzumyan, D., Becher, O. J., & Brat, D. J. (2025). A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression. Proceedings of the National Academy of Sciences of the United States of America, 122(7), e2416024122.
McManus, D. T., Valanparambil, R. M., Medina, C. B., Scharer, C. D., McGuire, D. J., Sobierajska, E., Hu, Y., Chang, D. Y., Wieland, A., Lee, J., Nasti, T. H., Hashimoto, M., Ross, J. L., Prokhnevska, N., Cardenas, M. A., Gill, A. L., Clark, E. C., Abadie, K., Kumar, A. J., Kaye, J., … Ahmed, R. (2025). An early precursor CD8+ T cell that adapts to acute or chronic viral infection. Nature, 640(8059), 772–781.
+Ross, J. L., +Puigdelloses-Vallcorba, M., +Piñero, G., +Soni, N., Thomason, W., DeSisto, J., Angione, A., Tsankova, N. M., Castro, M. G., Schniederjan, M., Wadhwani, N. R., Raju, G. P., Morgenstern, P., Becher, O. J., Green, A. L., Tsankov, A. M., & Hambardzumyan, D. (2024). Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations. Immunity, 57(11), 2669–2687.e6. +equal contribution of authors.
Ross, J. L., & Hambardzumyan, D. (2023). Et tu neutrophils? The brain reprograms neutrophils to facilitate tumor progression. Immunity, 56(11), 2469–2471.
Chen, Z., Giotti, B., Kaluzova, M., Vallcorba, M. P., Rawat, K., Price, G., Herting, C. J., Pinero, G., Cristea, S., Ross, J. L., Ackley, J., Maximov, V., Szulzewsky, F., Thomason, W., Marquez-Ropero, M., Angione, A., Nichols, N., Tsankova, N. M., Michor, F., Shayakhmetov, D. M., … Hambardzumyan, D. (2023). A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression. The Journal of clinical investigation, 133(22), e163802.
McSwain, L. F., Pillsbury, C. E., Haji-Seyed-Javadi, R., Rath, S. K., Chen, V., Huang, T., Shahab, S. W., Kunhiraman, H., Ross, J., Price, G. A., Dey, A., Hambardzumyan, D., MacDonald, T., Yu, D. S., Porter, C. C., & Kenney, A. M. (2023). YB1 modulates the DNA damage response in medulloblastoma. Scientific reports, 13(1), 8087.
Chen, Z., Soni, N., Pinero, G., Giotti, B., Eddins, D. J., Lindblad, K. E., Ross, J. L., Puigdelloses Vallcorba, M., Joshi, T., Angione, A., Thomason, W., Keane, A., Tsankova, N. M., Gutmann, D. H., Lira, S. A., Lujambio, A., Ghosn, E. E. B., Tsankov, A. M., & Hambardzumyan, D. (2023). Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma. Nature communications, 14(1), 1839.
Hashimoto, M., Araki, K., Cardenas, M. A., Li, P., Jadhav, R. R., Kissick, H. T., Hudson, W. H., McGuire, D. J., Obeng, R. C., Wieland, A., Lee, J., McManus, D. T., Ross, J. L., Im, S. J., Lee, J., Lin, J. X., Hu, B., West, E. E., Scharer, C. D., Freeman, G. J., … Ahmed, R. (2022). PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program. Nature, 610(7930), 173–181.
Lee, H., Guo, Y., Ross, J. L., Schoen, S., Jr, Degertekin, F. L., & Arvanitis, C. (2022). Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade. Science advances, 8(46), eadd2288.
Markwell, S. M., Ross, J. L., Olson, C. L., & Brat, D. J. (2022). Necrotic reshaping of the glioma microenvironment drives disease progression. Acta neuropathologica, 143(3), 291–310.
Morgan, M. B., Ross, J., Ellwanger, J., Phrommala, R. M., Youngblood, H., Qualley, D., & Williams, J. (2022). Sea Anemones Responding to Sex Hormones, Oxybenzone, and Benzyl Butyl Phthalate: Transcriptional Profiling and in Silico Modelling Provide Clues to Decipher Endocrine Disruption in Cnidarians. Frontiers in genetics, 12, 793306.
Ross, J. L., Velazquez Vega, J., Plant, A., MacDonald, T. J., Becher, O. J., & Hambardzumyan, D. (2021). Tumour immune landscape of paediatric high-grade gliomas. Brain : a journal of neurology, 144(9), 2594–2609.
Chen, Z., Herting, C. J., Ross, J. L., Gabanic, B., Puigdelloses Vallcorba, M., Szulzewsky, F., Wojciechowicz, M. L., Cimino, P. J., Ezhilarasan, R., Sulman, E. P., Ying, M., Ma'ayan, A., Read, R. D., & Hambardzumyan, D. (2020). Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. Glia, 68(10), 2148–2166.
Kaffes, I., Szulzewsky, F., Chen, Z., Herting, C. J., Gabanic, B., Velázquez Vega, J. E., Shelton, J., Switchenko, J. M., Ross, J. L., McSwain, L. F., Huse, J. T., Westermark, B., Nelander, S., Forsberg-Nilsson, K., Uhrbom, L., Maturi, N. P., Cimino, P. J., Holland, E. C., Kettenmann, H., Brennan, C. W., … Hambardzumyan, D. (2019). Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. Oncoimmunology, 8(11), e1655360.
Chen, Z., Ross, J. L., & Hambardzumyan, D. (2019). Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages. Proceedings of the National Academy of Sciences of the United States of America, 116, 14254–14259.
Qualley, D. F., Cooper, S. E., Ross, J. L., Olson, E. D., Cantara, W. A., & Musier-Forsyth, K. (2019). Solution Conformation of Bovine Leukemia Virus Gag Suggests an Elongated Structure. Journal of molecular biology, 431(6), 1203–1216.
Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, Ljungman M, Qin T, Sartor MA, Tagett R, Venneti S, Brosnan-Cashman J, Meeker A, Gorbunova V, Zhao L, Kremer DM, Zhang L, Lyssiotis CA, Jones L, Herting CJ, Ross JL, Hambardzumyan D, Hervey-Jumper S, Figueroa ME, Lowenstein PR, Castro MG. (2019). IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response. Science translational medicine, 11(479), eaaq1427.
Ross, J. L., Cooper, L. A. D., Kong, J., Gutman, D., Williams, M., Tucker-Burden, C., McCrary, M. R., Bouras, A., Kaluzova, M., Dunn, W. D., Jr, Duong, D., Hadjipanayis, C. G., & Brat, D. J. (2017). 5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins. Scientific reports, 7(1), 15593.
Zhang, C., Mukherjee, S., Tucker-Burden, C., Ross, J. L., Chau, M. J., Kong, J., & Brat, D. J. (2017). TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Molecular oncology, 11(3), 280–294.
Selagea, L., Mishra, A., Anand, M., Ross, J., Tucker-Burden, C., Kong, J., & Brat, D. J. (2016). EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(12), 4098–4108.
Morgan, M., Goodner, K., Ross, J., Poole, A. Z., Stepp, E., Stuart, C. H., Wilbanks, C., & Weil, E. (2015). Development and application of molecular biomarkers for characterizing Caribbean Yellow Band Disease in Orbicella faveolata. PeerJ, 3, e1371.
Qualley, D. F., Sokolove, V. L., & Ross, J. L. (2015). Bovine leukemia virus nucleocapsid protein is an efficient nucleic acid chaperone. Biochemical and biophysical research communications, 458(3), 687–692.
Teng, Y., Ross, J. L., & Cowell, J. K. (2014). The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAK-STAT, 3(1), e28086.
Xie, X., Ross, J. L., Cowell, J. K., & Teng, Y. (2015). The promise of zebrafish as a chemical screening tool in cancer therapy. Future medicinal chemistry, 7(11), 1395–1405.